The theme of this project is computing life, i.e., representing living systems as biochemical reaction networks or "biological circuits" and using these reaction networks to predict the response of living systems as a whole. Neurospora crassa has provided much of what we know about biological clocks at the molecular level. The goal of this computing life project is to construct a reaction network that allows us to predict how the biological clock responds to environmental (i.e., light), genetic (i.e., gene knockouts), and chemical perturbations (i.e., caffeine). This system provides a paradigm foran eukaryotic oscillator. Many of the techniques developed by physicists for kinetic theory are used in this project.

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